VIP

VIP is a neuropeptide studied for its interaction with two closely related receptors, VPAC1 and VPAC2. These targets belong to the class B family of G protein-coupled receptors, making VIP relevant to research on how peptide signals are recognized at the cell surface.

Research context

Primary receptor studies compare VIP with modified analogues to examine binding and adenylate cyclase activation. Changes in peptide structure can alter how strongly an analogue interacts with each receptor, providing a way to investigate receptor selectivity.

Structural and molecular-simulation research also examines how VIP fits within receptor binding sites and how receptor shape changes during activation. Together, these approaches connect peptide structure, receptor recognition and downstream signaling without treating them as interchangeable measurements.

Class B G protein-coupled receptors recognize their peptide ligands through a two-domain mechanism in which the receptor’s extracellular region and its transmembrane core each contribute to binding. Research on VIP and its analogues helps map how peptide sequence and receptor structure cooperate in that recognition process, a question shared across the wider class B receptor family.

Quality, Purity and Documentation

Review the analytical documentation listed for the selected size. Reports describe the samples identified in them; they do not by themselves confirm that current stock matches those samples. If no matching report is listed, contact Prestige Peptides for documentation before ordering.

Planned format

VIP 10mg is planned as a lyophilized (freeze-dried) powder in a sealed 10mg vial. Lyophilization removes water under vacuum at low temperature, producing a dry preparation suited to controlled laboratory storage. This listing is pending release; the notification form on this page registers interest for availability updates.

Storage and handling

Store lyophilized vials at -20°C or below, protected from light and moisture. Allow sealed vials to equilibrate to room temperature before opening to limit condensation inside the vial. Once opened, handle with clean laboratory technique, minimize exposure to ambient humidity, reseal promptly, and record the lot number in laboratory documentation for traceability.

For qualified in-vitro laboratory research only. Not for human or animal use.